Incidental detection of methemoglobinemia in a patient with lignocaine toxicity: A case report
Year: 2026
Type: article
Study design: Case Report
Abstract: Methemoglobinemia is a rare but potentially life-threatening haematological disorder characterized by an increased concentration of methemoglobin, which impairs oxygen transport and results in cyanosis. The condition is divided into two forms, acquired and congenital. Acquired methemoglobinemia is most commonly triggered by exposure to oxidizing agents such as dapsone, local anaesthetics, and certain antibiotics, while congenital forms are linked to genetic mutations affecting the cytochrome b5 reductase enzyme or the presence of hemoglobin M variants. This case report presents a middle-aged female who developed acquired methemoglobinemia following the administration of local anaesthesia during a routine root canal procedure. She exhibited sudden onset of hypoxemia, loss of consciousness, and abnormal body movements, followed by persistent oxygen desaturation. The diagnosis of methemoglobinemia was promptly made, and the patient was treated according to standard protocols, resulting in a marked clinical improvement. This case underscores the importance of recognizing methemoglobinemia as a potential complication of local anaesthetic use and highlights the need for timely intervention to prevent severe outcomes.
Authors: Deepak Kumar, Ajay Bade, Vishal Vaibhaw, Divendu Bhushan, Aaruni Rahul, Sunil Kumar, Lalit Gupta
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7153326852
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