Physical Inactivity and Quality of Life in Frail Dialysis Patients
Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Background Chronic kidney disease (CKD) leads to progressive kidney function decline, predisposing patients to frailty and reduced quality of life. Regular physical activity can benefit those undergoing renal replacement therapy. Objectives To evaluate the impact of physical activity on frailty and quality of life in CKD patients undergoing hemodialysis. Methods A cross-sectional, descriptive study with 64 CKD patients undergoing hemodialysis. Frailty was assessed using handgrip dynamometry, the 10-meter walk test, self-reported weight loss, and the International Physical Activity Questionnaire. Quality of life was measured using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Results The study identified 41 patients as pre-frail, 20 as frail, and 1 as non-frail. In comparing the frail and pre-frail groups, both exhibited a decline in quality of life. Significant differences were found between the groups in the physical, mental health, and overall domains, with the frail group showing worse outcomes. Additionally, both groups exhibited reduced levels of physical activity. Conclusions CKD patients undergoing hemodialysis demonstrate low levels of physical activity, frailty, and impaired quality of life.
Source: Research Square
Institutions: Universidade Federal de Sergipe, Universidade Tiradentes
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7154237357