Retrospective Analysis Of The Combined Effects Of Vitamin E And Pentoxifylline In Post- Radiation Recovery Of Head And Neck Cancer Patients At Tertiary Care Center, Anand
Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Introduction Radiation therapy is a cornerstone of cancer treatment, but its side effects, including pain, delayed wound healing, and radiation-induced complications, significantly impact patients' quality of life. Pentoxifylline and Vitamin E have been suggested as adjunct therapies to mitigate these adverse effects. This study evaluates the efficacy of these agents in improving pain scores, wound healing, and radiation-related complications in cancer patients. Aim This study aims to assess the effectiveness of Pentoxifylline and Vitamin E in reducing pain, enhancing wound healing, and minimizing radiation-induced side effects in patients undergoing radiation therapy. Materials and Methods This retrospective study analyzed clinical data from cancer patients receiving radiation therapy, divided into a treatment group (Pentoxifylline and Vitamin E) and a control group. Patients were categorized based on cancer stage and treatment regimens. Data on radiation dosage, pain scores, wound healing rates, and radiation-related side effects were collected and statistically analyzed. Results Patients in the treatment group, particularly those in advanced cancer stages, experienced significantly lower pain scores compared to controls (p-values < 0.0001 for Stage 2 and 0.0004 for Stage 4). Wound healing was notably faster in Stages 2, 3, and 4, with statistically significant improvements (p = 0.01, 0.03, and 0.05, respectively). However, the treatment group did not show a reduction in radiation-induced side effects, with an unexpected increase in xerostomia cases (p = 0.0026). Radiation dose analysis revealed that patients in the treatment group were more likely to receive higher radiation doses (66Gy/33# and 70Gy/33#), suggesting a potentially more aggressive treatment approach. Conclusion The combination of Pentoxifylline and Vitamin E appears to provide significant pain relief and improved wound healing, particularly in advanced cancer stages. However, its impact on radiation-induced side effects remains unclear, with a potential association with increased xerostomia. Further research is required to optimize treatment protocols, refine dosage strategies, and explore the mechanisms underlying these effects to improve supportive care in cancer patients undergoing radiation therapy.
Source: Research Square
Institution: Shree Krishna Hospital
Language: English
Subfield: General Dentistry
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7155013239