Work

Pyrazole–triazole hybrids as kinase-triad inhibitors: a triple-target strategy for synergistic anticancer therapy

Year: 2026

Type: article

Abstract: ADME profiling indicated favorable drug-likeness, especially for series 7. These findings identify compounds 7i and 10a as potential dual-scaffold leads for subsequent preclinical development as multi-target anticancer agents.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d6md00022c

Authors: Mahmoud S. Elkotamy, Mohamed K. Elgohary, Mariam M. Fakhry, Mohamed E. Albakri, Abdelrahman A. Naglah, Abdulrahman A. Almehizia, Ahmed M. Naglah, Mohamed Fares, Haytham O. Tawfik, Wagdy M. Eldehna, Hatem A. Abdel-Aziz

Institutions: Egyptian Russian University, Zagazig University, King Saud University, The University of Sydney, Tanta University, Kafrelsheikh University, National Research Centre

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: King Saud University

Award: G5642898733

OpenAlex ID: W7155192886

FWCI: 8.005

Cites: 92

Cited by: 5

Related to: 10