SPaCeD: Spatial Point Process Distances for Pairing the Heavy and Light Chains of B Cell Receptors from Spatial BCR-seq
Year: 2026
Type: preprint
Abstract: B cells mediate anti-tumor immunity through B cell receptors (BCRs) composed of paired heavy and light chains. Leveraging spatial transcriptomics, we introduce SPaCeD, a framework that infers heavy–light chain pairs by integrating expression matrices with spatial distances between point patterns derived via optimal transport. Applied to ovarian and breast cancer datasets and simulation scenarios, SPaCeD improves pairing accuracy and stability compared with existing methodology ( Repair ), particularly for pairs with lower spatial expression.
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7155195288