Features of the influence of physical and chemical factors (at the level of 1.5 MPC) on accelerated aging of model organisms (based on the results of physiological, genetic and morphohistological studies)
Year: 2026
Type: article
Abstract: Annotation. The aim of the study is to evaluate the influence of physical and chemical factors (at the level of 1.5 MPC) on the development of accelerated aging of model organisms (based on the results of original physiological, genetic and morphohistological studies and data from a literature review), to establish the primary changes that trigger the processes of premature aging to prevent these processes. Material and methods. In the analysis of the assessment of the risks of accelerated (cellular) aging in model organisms that were 180 days under periodic isolated exposure to physical and chemical factors, methods of hygienic diagnosis and theoretical research were used: formalization, generalization, comparison, system analysis. The object of the research was the material of his own original research, as well as the results of the scientific activities of other authors available in scientific journals on this subject. The results and their discussion. The study determined a direct relationship between the duration of exposure to physical and chemical factors (at the level of 1.5 MPC) on the health of model organisms, and their accelerated aging (according to the degree of shortening of telomere lengths, the presence of pathological changes in 2 or more internal organs, a decrease in behavioral reactions, external manifestations of aging). The conducted research will allow for a deeper understanding of the processes leading to the development of accelerated aging, which directly affects health and life expectancy. Conclusion. The study identifies the leading role of health-saving measures in preventing the development of accelerated aging, which will undoubtedly contribute to an increase in life expectancy.
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7160053041