Glycoprotein-p (abcb1): Structural-functional Organization, Molecular-genetic Mechanisms of Activity Regulation, Molecular Mechanism of Action and Clinical Signi Cance in Multiple-drug Resistance
Year: 2026
Type: article
Abstract: P-glycoprotein (ABCB1) is a key component of the body’s biodefense system, mediating ATP-dependent transport of a wide range of xenobiotics and drugs. This review analyzes the structural and functional characteristics of this transmembrane protein of the ABC transporter family. The molecular architecture of P-glycoprotein is described. The mechanisms of transcriptional regulation of protein expression via nuclear receptors (PXR, CAR) are discussed, as well as the post-translational modi cations that determine its activity and sensitivity to inducers and inhibitors. The clinical signi cance of P-glycoprotein in the context of multidrug resistance in cancer, as well as its role in the pharmacokinetics and bioavailability of therapeutic drugs, are analyzed.
Institution: Chelyabinsk State University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7161069199