Work

Clinical characteristics and treatment patterns of tenosynovial giant cell tumor in Japan: an analysis of the Japanese bone and soft tissue tumor registry

Year: 2026

Type: article

Abstract: Background Tenosynovial giant cell tumors (TGCTs) are rare proliferative disorders arising from the synovium of the joints, tendon sheaths, and bursae. Despite being generally considered a benign disease, it can cause pain, joint dysfunction, and local recurrence. We investigated TGCT epidemiological characteristics and treatment patterns in Japan using data from the Japanese Bone and Soft Tissue Tumor (BSTT) registry and a nationwide institutional survey. Methods A retrospective analysis was performed using the BSTT registry maintained by the Musculoskeletal Tumor Committee of the Japanese Orthopedic Association. Patients diagnosed with TGCT between 2006 and 2019 were included. Demographic characteristics, tumor presentation, diagnostic procedures, and surgical treatments within 1 year of registry entry were analyzed. Results Overall, 3,779 patients with TGCT were identified. The mean age at diagnosis was 44.9 years (range, 4–97 years), and 62.1% of patients were women. Most tumors presented as solitary lesions (99.0%). Biopsies were performed in 1,148 patients. Surgical treatment within 1 year of registry entry was recorded in 2,875 patients (76.1%); 888 did not undergo surgery, and surgical status was unknown for 16. Functional outcome assessments using the International Society of Limb Salvage scores were available for 177 patients. Conclusions This study overviewed the demographic characteristics and initial treatment patterns of TGCT in Japan. Clinical features were broadly consistent with those reported internationally, and surgery remained the primary management strategy. Longer follow-up and more detailed tumor subtype information are warranted to better characterize the natural history and optimize management strategies. Mini abstract Nationwide registry analysis of 3,779 TGCT cases in Japan showed predominance of middle-aged women, mainly solitary lesions, and surgery as the primary treatment, consistent with international findings.

Source: International Journal of Clinical Oncology

DOI: 10.1007/s10147-026-03175-z