Work

The history of hemoglobin-based oxygen carriers: a narrative review

Year: 2026

Type: review

Abstract: Hemoglobin-based oxygen carriers (HBOCs) are compounds designed to allow for oxygen-carrying capacity and tissue delivery without the red blood cell (RBC) compatibility concerns, storage constraints, side effects, and adverse outcome profile of allogeneic blood products. Significant investments in time, resources, intellect, and hope have been made in HBOC development over the past ninety years. This narrative review describes the history of HBOC development.

Source: Annals of Blood

DOI: 10.21037/aob-2025-1-46

Authors: Erica A. Swenson, Maryam Asif, Deborah Tolich, Gaurav K. Gupta, Joyisa Deb, Sarah Walbolt, Bruce Spiess

Institutions: University of Utah, University of Washington, Cleveland Clinic, Memorial Sloan Kettering Cancer Center, University of Florida Health, University of Florida

Language: English

Topic: Hemoglobin structure and function

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7163581985

FWCI:

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