Work

Evaluation of Anti-Ulcerogenic Effect of Castanopsis costata Extract Against Experimental Gastric Ulcer in Rats

Year: 2026

Type: article

Abstract: Gastrointestinal diseases, such as gastric ulcer (GU), are caused by damage to the GM, alcohol consumption, NSAIDs (specifically ketorolac), and Helicobacter pylori. Currently, several plants are effective in treating GU, including Castanopsis costata. Until now, there has been no report regarding the antiulcerogenic effects of ethanolic extract of C. costata (EECc) reported. Therefore, this research aimed to test antiulcerogenic potential of EECc in 3 rat models of GU induced by ethanol (EtOH) 1 mL orally, ketorolac (30 mg/kg orally), and H. pylori (1.0×109 CFU intragastrically). Each treatment group in the experimental model was given EECc 50, 100, and 200 mg/kg orally. In this context, GpH and GV, FA and TA, as well as UI, were measured to assess gastric function. Measurements of inflammatory cytokines levels, as well as histopathological examination of tissue, were carried out to determine the effects of organ damage. Anti-H. pylori activity was tested in vitro and in vivo to assess the inhibition of H. pylori growth. The results showed that EECc improved gastric function, reduced the levels of TNF-α, IL-1β, and IL-6, increased PGE2, inhibited the growth of H. pylori in vitro and in vivo, and improved tissue architecture by reducing the severity of GM injury, leukocyte infiltration, and bleeding. Moreover, EECc had antiulcerogenic effects in EtOH-, ketorolac-, and H. pylori-induced GU rat models. HIGHLIGHTS Castanopsis costata is a traditional medicine to treat fever, various digestive disorders, and analgesic. The ethanolic extract of Castanopsis costata exhibited anti-ulcerogenic activity against experimental gastric ulcer in rats (ethanol-induced, ketorolac-induced, and pylori-induced gastric ulcer). The study also demonstrated that ethanolic extract of Castanopsis costata exhibits significant anti- pylori activity in vitro and in vivo. GRAPHICAL ABSTRACT

Source: Trends in Sciences

DOI: 10.48048/tis.2026.13458