Year: 2026
Type: article
Abstract: This study compiles recent advances in the synthesis, design, and biological evaluation of novel coumarin analogs as antitubercular medications. The influence of changes at C-3, C-4, C-6, and C-7 positions is emphasized in structure-activity relationship (SAR) investigations. One of the leading causes of infectious death worldwide is the emergence of extensively drug-resistant (XDR) and multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, which causes tuberculosis (TB). Key mycobacterial targets include DNA gyrase, enoyl-acyl carrier protein reductase (InhA), and cell wall biosynthesis enzymes may be inhibited, according to mechanistic findings. Moreover, it has been demonstrated that improving physicochemical characteristics enhances intracellular penetration and macrophage targeting. Because of the urgent need for novel chemotherapeutic medications with improved efficacy and reduced resistance potential, heterocyclic scaffolds have drawn a lot of interest in medicinal chemistry. A unique pharmacophore with a range of biological activities, including potential antimycobacterial activity, is coumarin (2H-chromen-2-one).
Authors: Shivani Sharma, Yogendra Singh, Dinesh Kaushik
Institutions: MVN University, Hindu College of Pharmacy
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W7167339367