Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson’s disease
Year: 2026
Type: review
Study design: Study Protocol
Abstract: We describe the design of the first non-pharmacological Parkinson's disease prevention trials worldwide: the randomised 'Slow-SPEED' trials. Three trials examine the feasibility and preliminary efficacy of a gamified, remotely administered exercise intervention vs. active control over 18-36 months in complementary prodromal subgroups: iRBD(n = 110; Netherlands), hyposmia(n = 110; United Kingdom) or LRRK2/GBA1 mutation carriers(n = 600; United States). These trials will provide unique insights for large-scale Parkinson's prevention studies. Protocols are registered at ClinicalTrials.gov(NCT06193252[1-5-2024];NCT06600438[9-19-2024];NCT06993142[5-28-2025]).
Source: npj Parkinson s Disease
Authors: Thomas H. Oosterhof, Eleanor Mitchell, Alberto Ascherio, Stella Aslibekyan, Viktoria Azoidou, Kara Beasley, Yoav Ben-Shlomo, Eline Bunnik, Camille Carroll, Lana Chahine, Daniel Corcos, Jules M. Janssen Daalen, Karin D. van Dijk, Bauke W. Dijkstra, Lisanne Dommershuijsen, Ray Dorsey, Luc J. W. Evers, Rick C. Helmich, Martin Johansson, Lucy Norcliffe-Kaufmann, Jessi Keavney, Christine Klein, Matthew J. Kmiecik, Thomas Kustermann, Eric A. Macklin, Kenneth Marek, Sanne K. Meles, Sebastiaan Overeem, Carl M. Philpott, Angelique Pijpers, Ronald B. Postuma, Helen M. Rowbotham, Sabine Schootemeijer, Michael A. Schwarzschild, Tanya Simuni, Michael Sommerauer, Ambra Stefani, Kenan Steidel, Marcel Verbeek, Rick van der Vliet, Nienke M. de Vries, Bart van de Warrenburg, Richard K. Wyse, Bastiaan R. Bloem, Ruth B. Schneider, Alastair J. Noyce, Sirwan K. L. Darweesh
Institutions: Radboud University Nijmegen, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Queen Mary University of London, Harvard University, 23andMe (United States), Davis Phinney Foundation, University of Bristol, Erasmus MC, NIHR Newcastle Biomedical Research Centre, Newcastle University, University of Pittsburgh, Northwestern University, Stichting Epilepsie Instellingen Nederland, Amsterdam UMC Location Vrije Universiteit Amsterdam, University of Rochester Medicine, University of Rochester, Sorbonne Université, Pitié-Salpêtrière Hospital, Institut du Cerveau, Parkinson's Foundation, University Hospital Schleswig-Holstein, University of Lübeck, F. Hoffmann-La Roche AG, Massachusetts General Hospital, Institute for Neurodegenerative Disorders, University Medical Center Groningen, University of Groningen, Kempenhaeghe, University of East Anglia, James Paget University Hospital, McGill University, University Hospital Bonn, German Center for Neurodegenerative Diseases, Innsbruck Medical University, Universität Innsbruck, Philipps University of Marburg
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,890
Funders: Michael J. Fox Foundation for Parkinson's Research, Massachusetts General Hospital, F. Hoffmann-La Roche, Northwestern University, McGill University, Davis Phinney Foundation, Parkinson's Foundation, Parkinson's UK, University of East Anglia, Rijksuniversiteit Groningen, ZonMw, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Universitair Medisch Centrum Groningen, Deutsches Zentrum für Neurodegenerative Erkrankungen, Radboud Universitair Medisch Centrum, Sorbonne Université, Stichting Epilepsie Instellingen Nederland, Feinberg School of Medicine
OpenAlex ID: W7168238299