Work

Injectability and mechanical properties of borneol-based solvent removal-induced in situ matrix for periodontal pocket delivery

Year: 2026

Type: article

Abstract: Solvent removal-induced in situ matrices (ISMs) have garnered attention for periodontitis treatment because of their capability to localize antibiotic drug release within the periodontal pocket over an extended duration, effectively targeting and eliminating infecting microbes. In this study, various concentrations of borneol—10%–70%—were used as a matrix agent in ISMs, with a 40% w/w borneol-based ISM selected to load 1% vancomycin HCl. The injectability and mechanical properties of drug-free and vancomycin HCl-loaded borneol ISMs were evaluated with a texture analyzer. Both maximum injection force and energy increased proportionally with borneol concentrations and slightly further with vancomycin HCl. Nevertheless, the injection energy required for borneol-loaded ISMs at 10%–50% was low, from 12.22–25.00 mJ. Consequently, these formulations were considered appropriate and feasible as injectable drug delivery systems, providing ease of administration while promoting patient comfort and compliance. Additionally, a more compact borneol matrix was formed after complete solvent removal; it exhibited plastic deformation, enabling close adaptation to the periodontal pocket geometry.

Source: Asia-Pacific Journal of Science and Technology

DOI: 10.22299/apst.2026.280999

Authors: Nutdanai Lertsuphotvanit, Siraprapa Chansatidkosol, Tiraniti Chuenbarn, Thawatchai Phaechamud

Institutions: Burapha University, Silpakorn University

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Burapha University, Silpakorn University, Faculty of Pharmaceutical Sciences, Burapha University