Evaluation of etodolac and thiocolchicoside on cutaneous wound healing: an experimental rat study
Year: 2026
Type: article
Abstract: Aims: This experimental study aimed to evaluate the effects of etodolac and thiocolchicoside, administered alone or in combination, on cutaneous wound healing in a rat full-thickness excisional wound model using macroscopic, histopathological, and immunohistochemical parameters.Methods: This controlled experimental study was conducted using a full-thickness excisional wound model in 24 male Wistar albino rats. Animals were randomized into four groups (n=6 each): etodolac, thiocolchicoside, combination (etodolac+thiocolchicoside), and control. A standardized 2-cm dorsal skin wound was created under general anesthesia. Treatments were administered orally for 14 days. Wound areas were measured on postoperative days 0, 3, 7, 10, and 14. Histopathological evaluation and immunohistochemical analysis of CD31 and TGF-β1 were performed on day 14.Results: Baseline wound areas were comparable among groups (p=0.912). Significant intergroup differences in wound area reduction were observed on day 3 (p=0.041) and became more pronounced on days 7, 10, and 14 (all p
Institutions: Istanbul Medeniyet University, Düzce Üniversitesi
Language: English
Topic: Wound Healing and Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7169727886