Comparison of effectiveness and safety of narrow band ultraviolet B with and without platelet rich plasma in the treatment of vitiligo
Year: 2024
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Objective To compare efficacy and safety of Narrow Band Ultraviolet B with and without platelet rich plasma in the treatment of vitiligo. Methods A total of 74 patients took part in the trial who were randomly divided in two groups (37 in each group). Patients in Group-A were given NBUVB alone, whereas those in Group-B were given both NBUVB and PRP. The NB-UVB treatment protocol included twice-weekly sessions for up to three months, or until complete re-pigmentation had occurred. Patients in Group B had fortnightly PRP treatment for a total of 6 sessions over the course of 3 months. PRP was injected intradermally into the lesion. After the final session, the patients were followed up with for an additional month. Results Vitiligo patients benefited more from the NBUVB+PRP combination than from NBUVB alone. The effectiveness was statistically significant in group B (Group A: 64.9% vs. Group B: 91.9%, p-value=0.005). 35.1% of Group-A patients and 59.5% of Group-B patients achieved excellent treatment outcomes, according to evaluation criteria for effectiveness. While 30 percent of Group-A patients and 32 percent of Group-B patients had good treatment outcome, 35 percent of patients in Group-A and 8 percent in Group-B experienced moderate outcome. Both the treatments were safe and no serious or long-term adverse effects were noted. Conclusion This study's findings suggested that platelet-rich plasma (PRP) combined with narrowband ultraviolet B (NB-UVB) was a better therapy for vitiligo than NB-UVB alone. This treatment for vitiligo was cost-effective, risk-free, and well-tolerated. It reduced the time spent in NB-UVB treatment, which should improve adherence.
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7170200232