Year: 2026
Type: article
Abstract: Electrolyte-gated organic transistors (EGOTs) are emerging as promising devices for biosensing applications due to their high transconductance, ability to operate in liquid environments at low voltages and label-free detection capabilities. In this study, we investigate the performance of EGOTs based on the donor-acceptor polymer DPP-DTT, a material known for its high charge mobility and aqueous stability. The device was tested as a biosensor for the detection of mitochondrial DNA (mtDNA), a biomarker associated with multiple sclerosis, as a model analyte. The gate electrode was functionalized with a complementary DNA probe via surface chemistry, with functionalization efficiency validated by surface plasmon resonance and plasmon-enhanced fluorescence spectroscopy. The resulting DPP-DTT-based EGOT sensor exhibited specific detection of mtDNA in solution, with a detection range from 70 pM to 5 nM. These results highlight the potential of DPP-DTT based EGOTs as stable, sensitive platforms for biosensing applications.
Source: Biosensors and Bioelectronics X
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,490
Funders: Fondazione Italiana Sclerosi Multipla, Associazione Italiana Sclerosi Multipla, Gesellschaft für Forschungsförderung Niederösterreich, European Commission, Ministerstvo Školství, Mládeže a Tělovýchovy, Österreichische Forschungsförderungsgesellschaft, H2020 Marie Skłodowska-Curie Actions, Ministero dell'Istruzione e del Merito, NextGenerationEU
OpenAlex ID: W7171663270