Year: 2026
Type: article
Study design: Observational Study
Abstract: Aim. To investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) level and the nature and severity of clinical manifestations in patients with chronic heart failure (CHF). Material and methods. A total of 85 patients with CHF hospitalized in the cardiology department were examined. hs-CRP was measured in all patients, who were stratified according to heart failure type, NYHA functional class, and main etiology. Statistical analysis included descriptive statistics, the Kruskal-Wallis test, and Dunn’s test with Bonferroni correction for post-hoc comparisons. Results. hs-CRP level significantly varied depending on the studied parameters. Concentration progressively increased from isolated left ventricular failure (median 4.8 mg/L) to right ventricular failure (6.7 mg/L), reaching a maximum in total biventricular failure (8.4 mg/L; p=0.008). Post-hoc analysis confirmed a significant difference only between total and isolated left ventricular failure (padj<0.001). hs-CRP increased with worsening NYHA class: medians were 4.4, 7.3, and 11.2 mg/L for classes II, III, and IV, respectively (p<0.001), with significant pairwise differences. Systemic inflammation activity also varied by CHF etiology. The highest hs-CRP values were recorded in valvular defects (7.5 mg/L) and dilated cardiomyopathy (5.2 mg/L), whereas hypertensive etiology showed the lowest levels (4.7 mg/L; p=0.03). Post-hoc analysis revealed significant difference only between valvular defects and arterial hypertension (padj=0.03). Discussion. Elevated hs-CRP reflects the severity of hemodynamic disturbances and systemic inflammation associated with congestion and neurohormonal activation. The highest concentration in total CHF confirms the link between congestion severity and inflammatory response. Etiological differences indicate the need for differentiated interpretation of hs-CRP levels. Conclusions. hs-CRP can serve as an additional laboratory marker for objectifying CHF severity and patient stratification, especially in pronounced congestion. Key words: chronic heart failure, systemic inflammation, high-sensitivity C-reactive protein, NYHA functional class, etiology.
Authors: Ш.Р. Косимова, С.М. Шукурова
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7171838121