Huntington’s disease: Characterization and survival analysis of a patient series in northern Brazil
Year: 2026
Type: article
Study design: Observational Study
Abstract: Introduction: Huntington’s disease (HD) is a neurodegenerative condition characterized by motor, cognitive, and psychiatric dysfunctions. Materials and methods: A retrospective cohort study including 14 participants treated at a private neurology clinic from 2003 to 2023 in Santarém, Pará, Brazil. Results: The mean age at diagnosis was 43.5 ± 6.5 years. Motor manifestations were the most prevalent, particularly chorea (92.86%). The mortality rate during the study period was 21.42%, and 92.86% of patients progressed to dementia, with 76.9% presenting with early-onset dementia. No correlations were found between the variables studied and the development of early-onset dementia. Discussion: Although this is a small sample followed over a twenty-year period, establishing causal relationships is subject to limitations, and the generalizability of the results remains restricted. Nevertheless, these findings remain valid, particularly in the northern region of Brazil, where access to genetic testing remains limited, potentially contributing to underreporting and masking of inheritance patterns or atypical variants. Conclusion: The study revealed findings both consistent with and divergent from those reported in the literature, highlighting a unique disease profile in this region.
Source: Acta neurológica colombiana
DOI: 10.22379/anc.2026
Institution: Universidade do Estado do Pará
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7197042958