Myélome multiple (MM) et compression médullaire au service d’hématologie du CHU d’Ignace Deen
Year: 2026
Type: article
Study design: Observational Study
Abstract: Introduction: Multiple myeloma (MM) is characterized by tumor proliferation of monoclonal plasma cells invading the bone marrow and secreting a monoclonal immunoglobulin. Spinal cord compression is observed in approximately 5% of cases of multiple myeloma. Method: This was a two-year descriptive cross-sectional study conducted from October 1, 2023, to September 30, 2025. It included all patients with multiple myeloma associated with spinal cord compression. Results: We identified 18 cases of spinal cord compression among patients with multiple myeloma, representing 25.7% of cases. The sex ratio was 1.57. The mean age was 40 ± 3.2 years. Seventy percent of patients consulted after 12 months. All patients presented with functional impairment of the lower limbs, including loss of motor function in five cases. Radiological findings included pathological compressive fractures in eight cases, epiduritis in six cases, and solitary plasmacytoma in four cases. Biologically, anemia was present in all patients, while hypercalcemia was observed in 55.5% of cases. According to the International Staging System (ISS), 44.5% of patients were stage III. Conclusion: This study demonstrates a significant frequency of spinal cord compression, especially in the context of delayed diagnosis.
Source: European Scientific Journal ESJ
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7201860916