An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation
Year: 2026
Type: article
Source: Science Immunology
Authors: Mariko Aoki, Alberto Iannuzzo, Philippe Mertz, Shouya Feng, Naoya Iwata, Chiara Perugini, Naomi Tsuchida, Rana El Masri, Yoshihiko Kuchitsu, Rachida Tacine, Simona Coppola, Hirofumi Shibata, Margaux Cescato, Masahiko Nishitani-Isa, Alexandre Terré, Yuri Kawasaki, Sarah Dalmon, Kenichi Nishimura, Flora Magnotti, Satoko Miyatake, Marc André, Keisuke Hamada, Jonathan London, Kazushi Izawa, Akira Niwa, Nobuhiko Okamoto, Kazuhiro Ogata, Masashi Nishikawa, Erika Zara, Megumu K. Saito, Marco Tartaglia, Shuichi Ito, Mathieu P. Rodero, Koh-ichi Nagata, Asma Smahi, Naomichi Matsumoto, Laurent Le Corre, Junko Takita, Guilaine Boursier, Atsushi Hijikata, Thomas Henry, Tomohiko Taguchi, Véronique Hentgen, Sophie Georgin-Lavialle, Yoshitaka Honda, Seth L. Masters, Takahiro Yasumi, Jérôme Delon
Institutions: Kyoto University, Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Institut Cochin, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Centre de Référence des Maladies Autoinflammatoires et des Amyloses, Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine, Centre Hospitalier de Versailles, Hôpital Tenon, ERN RITA, The University of Melbourne, Walter and Eliza Hall Institute of Medical Research, Hudson Institute of Medical Research, Monash University, Yokohama City University Hospital, Yokohama City University, Tohoku University, Istituto Superiore di Sanità, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Center for iPS Cell Research and Application, Kyoto University, Lyon 1 Université, École Normale Supérieure de Lyon, Centre International de Recherche en Infectiologie, Université Clermont Auvergne, Microbe, Intestine, Inflammation and Host Susceptibility, Groupe Hospitalier Diaconesses Croix Saint-Simon, Osaka Women's and Children's Hospital, International University of Health and Welfare, Nagoya University, Bambino Gesù Children's Hospital, Institute for Developmental Research, Sorbonne Paris Cité, Institut des Maladies Génétiques Imagine, Université Paris Descartes, Medical Genome Center, National Center of Neurology and Psychiatry, Université de Montpellier, Centre Hospitalier Universitaire de Montpellier, Institute for Regenerative Medicine & Biotherapy, Tokyo University of Pharmacy and Life Sciences, Institute for the Advanced Study of Human Biology, Kyoto University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: closed
Funders: Japan Agency for Medical Research and Development, Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Ministero della Salute, Istituto Superiore di Sanità, National Health and Medical Research Council, Japan Society for the Promotion of Science, Japan Science and Technology Agency
Awards: 日本における歴史文献および史料の総合的調査研究, G1712723986, G2179763349, Diagnosis and Therapy based on new Mechanisms of Autoinflammatory Disease, Fostering Interdisciplinarity and Research Excellence for society at Université de Paris, G3114872835, The Centre of Excellence in Autoinflammatory Disease Research, G434444879, Control of cytoskeleton -mediated inflammation, G4919400370, G5062294628, G5097369954, G5961482988, G649412278, G6551196276, G685209070, G6871998606, G7379884263, G8796931231
OpenAlex ID: W7201863604