Work

Longitudinal Endoscopic Analysis of Ulcerative Colitis-Associated Neoplasia

Year: 2026

Type: article

Abstract: Ulcerative colitis (UC) is a chronic inflammatory disease of the colorectum characterized by a relapsing–remitting course. Patients with long-standing UC possess a heightened risk of developing colitis-associated neoplasia (CAN) through the well-established inflammation–dysplasia–carcinoma sequence. Current clinical guidelines recommend scheduled surveillance colonoscopy for high-risk individuals to facilitate early recognition of CAN, a strategy that directly influences clinical outcomes.1 Historically, early CAN was challenging to detect endoscopically, and given its frequent multifocal distribution, pancolectomy was traditionally regarded as the standard treatment approach.

Source: Gastro Hep Advances

DOI: 10.1016/j.gastha.2026.101089