Status of coronary arteries in patients with acute ischemic stroke depending on the presence of myocardial injury
Year: 2026
Type: article
Study design: Observational Study
Abstract: Aim. To assess the frequency of obstructive coronary artery disease (CAD) and coronary calcium score (CCS) measured by coronary computed tomography angiography (CTCA) in patients with IS depending on the presence of myocardial injury (MI), the association between clinical and laboratory parameters and the absence of coronary calcification. Mat erials and methods. In a prospective registry study, 50 patients (median age 60 (52; 66) years) with confirmed IS underwent CTCA. HsTn-I was obtained on admission and repeated within 48 hours. Results. CTCA did not detect significant coronary stenoses in 8 (44.4%) of 18 patients with acute MI, in 3 (33.3%) of 9 patients with chronic MI, and in 15 (65.3%) of 23 patients without MI. In patients with and without MI a CCS was comparable: 143 (0; 266) vs 68 (4; 205), respectively (p = 0.662). There was no statistically significant difference between hsTn levels in CCS categories of CAD risk. In multivariate regression analysis in patients with IS a change (D) in hsTn with a cutoff value of less than -2 ng/L increased odds ratio for absence of coronary calcification by 5.931 times (95% confidence interval 1.129–31.150; p = 0.035). Conclusions. About half of patients with IS and acute MI, 1/3 of patients with chronic MI, and almost 2/3 of patients without MI did not have obstructive CAD. Absolute change in hsTn was independently associated with the absence of coronary calcification in patients with IS.
DOI: 10.21518/ms2026-165
Institution: Botkin Hospital
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7202072850