Ventricular‐vascular coupling at rest and immediately following maximal exercise in adults with and without multiple sclerosis
Year: 2026
Type: article
Study design: Observational Study
Abstract: Multiple sclerosis (MS) may impair ventricular‐vascular coupling (VVC), a measure of the interaction between the cardiac and vascular systems. We evaluated if VVC differed between individuals with and without MS with similar age‐predicted fitness. Individuals with MS ( n = 20) and without (CON, n = 18) underwent VVC measurement before and immediately after a maximal incremental cycle test with peak oxygen consumption (VO 2 peak) measurement. VVC was quantified as the ratio of arterial elastance (E A : end‐systolic pressure (ESP)/stroke volume) to ventricular elastance (E LV : ESP/end‐systolic volume). ESP was assessed with radial applanation tonometry, and cardiac volumes were obtained from apical four‐chamber echocardiography. Sex, BMI and VO 2 peak were not different between groups. Individuals with MS were older, had higher E A ( p < 0.01) and E LV ( p = 0.02), but VVC did not differ between groups. After adjustment for age, the group differences in E A and E LV remained significant. VVC was similar between individuals with and without MS, before and immediately after maximal exercise. However, individuals with MS had higher E A and E LV , suggesting higher arterial and ventricular loads. Our data suggest that individuals with MS with similar fitness to controls exhibit higher E A and E LV with preserved coupling.
Source: Physiological Reports
DOI: 10.14814/phy2.71044
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,050
Funders: U.S. Department of Defense, American Heart Association, Bristol-Myers Squibb, University of Pennsylvania, Virginia Commonwealth University, NGM Biopharmaceuticals, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, U.S. Army Medical Command, Armed Forces Institute of Regenerative Medicine
Awards: HeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets - Clinical Centers, Blockade of calcium channels and beta adrenergic receptors for physiologic abnormalities in heart failure with preserved ejection fraction (BLOCK HFpEF), VASCULAR EFFECTS OF DIETARY SALT IN HUMANS WITH SALT-RESISTANT BP, Efficacy of Fenofibrate for COVID-19: A phase II randomized controlled trial, MECHANISMS OF LOW PHYSICAL WORK CAPACITY, FATIGUE, AND REDUCED MOBILITY IN MULTIPLE SCLEROSIS, G6260955739, Developing Oral LT3 Therapy for Heart Failure, G9000019884, Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal), Targeting Skeletal Muscle Perfusion and Oxidative Capacity in HFpEF, Genetic determinants of thoracic aortic stiffness and remodeling, Cardiovascular Risk, Vascular and Kidney Damage in COVID-19 Survivors, Cardiovascular Consequences of Duchenne and Becker Muscular Dystrophinopathies
OpenAlex ID: W7202264994