Work

Influence of Perioperative Variables on Surgical Site Infection in Patients With Frailty and Prefrailty Undergoing Coronary Artery Bypass Grafting: Retrospective Multicenter Study

Year: 2026

Type: article

Abstract: Background Surgical site infection (SSI) in patients with frailty undergoing myocardial revascularization is a major clinical challenge, and there is a gap in the literature related to this topic. Objective This study aimed to identify perioperative variables associated with SSI in patients with frailty and prefrailty undergoing coronary artery bypass grafting within 30 days of the procedure. Methods This retrospective observational study included 467 patients with frailty or prefrailty aged 60 years and older who underwent coronary artery bypass grafting in 6 Brazilian centers between January 2018 and December 2024. Frailty was defined using the Fried criteria. SSI was defined as a wound with exposed tissue with positive culture requiring antibiotic treatment. Univariate and multivariate analyses were carried out. Results The rate of SSI was 5.6% (26/467). The New York Heart Association classification ( P =.02), Charlson Comorbidity Index (CCI; P =.01), use of cardiopulmonary bypass (CPB; P =.003), CPB time ( P =.02), total surgery time ( P <.001), occurrence of bleeding ( P =.04), mechanical ventilation time ( P =.001), length of hospital stay ( P <.001), intensive care unit stay ( P <.001), and need for reoperation ( P <.001) variables were associated with SSI in unadjusted comparisons. In the multivariate model, the CCI (odds ratio 1.58, 95% CI 1.25‐1.99; P <.001) and use of CPB (odds ratio 4.89, 95% CI 1.71‐13.94; P =.003) were independently associated with SSI. Conclusions The CCI and the use of CPB were independently associated with SSI.

Source: JMIR Cardio

DOI: 10.2196/79408