Work

A systems-level model of sleep-dependent memory-consolidation failure in neurodegeneration: the spindle–slow-oscillation decoupling cascade dissociates amyloid and tau

Year: 2026

Type: software

Abstract: Simulation and analysis code for a systems-level model of the slow-oscillation–spindle–ripple consolidation cascade and its breakdown under Alzheimer's-like neurodegeneration. The realized spindle-to-up-state timing of each slow-oscillation window gates spike-timing-dependent plasticity, so coupling causally drives consolidation in the model. Running `run_analysis.py` reproduces every figure and numerical result reported in the accompanying paper (~20 minutes, CPU only). Requires Python 3.9+, NumPy, SciPy and Matplotlib. No empirical dataset is used or redistributed.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.21908471

Authors: masry, bahaa, Shahin, Anas, Malek, Zeina

Institutions: Damascus University, Syrian Virtual University, Arab International University

Language: English

Topic: Sleep and Wakefulness Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7202290191

Cites:

Cited by:

Related to: 10