Patient characteristics, treatment patterns and clinical response in patients with treatment resistant depression starting a new treatment in the clinical setting: a multicenter, observational study in Portugal
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: Treatment resistant depression (TRD) is a burdensome condition with a severe impact on patients' everyday lives. Therapeutics have improved in the last decade, however, outcomes remain poor. Real-world characterization has become increasingly important to accurately depict the clinical setting. ResisToday was an observational, prospective, multicenter study that aimed to increase available real-world evidence by evaluating clinical and socio-demographics, treatment patterns and clinical and patient-reported outcomes (PROs) of patients with TRD in Portugal. Methods: Patients with a clinical diagnosis of TRD and moderate to severe depression (Montgomery-Åsberg Depression Rating Scale [MADRS] score ≥22), who were initiating a new treatment for TRD could enroll in ResisToday. Clinical outcomes were evaluated using the MADRS and the Clinical Global Impression-Severity scale (CGI-S). PROs were reported using the Patient Health Questionnaire-9 (PHQ-9) and EuroQol 5-Dimension 5-Level (EQ-5D-5L) questionnaire. Outcomes were assessed at baseline, Week 4 (primary endpoint) and Week 20. Results: Of 153 patients, 123 (80.4%) were female and the mean age was 53.9 years. The mean age of onset of clinical depression symptoms was 38.0 years, and the mean time since diagnosis of major depressive disorder (MDD) was 11.8 years. TRD treatments initiated at baseline were varied; the most common treatments initiated or ongoing at baseline were mirtazapine (43.1%), venlafaxine (42.5%), quetiapine (25.5%), and trazodone (20.9%). Most patients' antidepressant treatment was augmented with an antipsychotic (36.6%), combined with additional antidepressants (22.2%), or combined with another augmentation strategy (19.0%). Improvements in MADRS were observed from baseline to Week 4 and Week 20 (both p<0.001). Clinical response and remission, assessed by MADRS, were achieved by 14.9% and 3.1% of patients, respectively, at Week 4, and 40.5% and 25.3% at Week 20. Improvements were observed across CGI-S, PHQ-9, and EQ-5D-5L measures through Week 20 (all p<0.001). Conclusions: Outcomes for patients with TRD in real-world clinical practice remain poor, with most patients not responding after 20 weeks of treatment. Treatment heterogeneity highlights a lack of clinical consensus, and the need for novel therapeutics and improved treatment protocols for TRD in real-world clinical practice in Portugal.
Source: Frontiers in Psychiatry
Authors: Ricardo Moreira, Patrícia Frade, Nuno Campeão, Sofia Gomes, Alice Lopes, Georgina Lapa, João Vian, Ana Fonseca, Flávia Polido, Bernardo Barata, David Mota, Patrício Ferreira, Yaroslava Martins, Miguel Nascimento, Licínio Santos, João Mendes, Diana Durães, Luís Ferreira, Dulce Maia, Nuno Cunha, Bárbara Cochicho, Gonçalo Amorim, André Ponte
Institutions: Unidade Local de Saúde do Oeste, Unidade Local de Saúde da Póvoa de Varzim/Vila do Conde, Unidade Local de Saúde de Santo António EPE, Unidade Local de Saúde Gaia/Espinho, Unidade Local de Saúde da Região de Leiria, Unidade Local de Saúde do Algarve, Unidade Local de Saúde do Arco Ribeirinho, Unidade Local de Saúde de Coimbra, Unidade Local de Saúde do Alto Minho, Unidade Local de Saúde do Baixo Alentejo, Unidade Local de Saúde de São José, Hospital Dr. Nélio Mendonça, Unidade Local de Saúde da Guarda EPE, Unidade Local de Saúde da Arrábida, Unidade Local de Saúde do Médio Tejo, Unidade Local de Saúde de Trás-os-Montes e Alto Douro, Unidade Local de Saúde de Viseu Dão-Lafões, Johnson & Johnson (United States), Hospital do Divino Espírito Santo
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: Johnson and Johnson
OpenAlex ID: W7202384489