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Novel Tetrahydropyridinyl-6,6-Bicyclic Compounds as 5-HT2A Receptor Agonists for Treating Depression, Anxiety, Substance Abuse, and Headaches

Year: 2026

Type: article

Abstract: Provided herein are novel tetrahydropyridinyl-6,6-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse and headaches, and processes for preparing such compounds.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.6c00430

Authors: Ram W. Sabnis, Anika R. Sabnis

Institution: Mayo Clinic

Language: English

Topic: Treatment of Major Depression

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7202391480