Herbal Nanoemulgel Systems And Marigold Phytotherapeutics
Year: 2026
Type: article
Abstract: Nanotechnology-based drug delivery systems have emerged as promising approaches to improve the therapeutic performance of poorly water-soluble drugs and bioactive compounds for topical and transdermal applications. This review summarizes recent advances in the development and evaluation of nanoemulsion- and nanoemulgel-based formulations incorporating natural products and conventional therapeutic agents, including curcumin, quercetin, 5-fluorouracil, lutein, carrot seed oil, rice bran oil, and paclitaxel. Various preparation techniques such as ultrasonication, spontaneous emulsification, high-pressure homogenization, interfacial deposition, and micro-titration were employed to produce stable nanosized formulations. The developed systems were characterized by particle size, polydispersity index, zeta potential, morphology, viscosity, pH, encapsulation efficiency, and thermodynamic stability. Their biological performance was evaluated through in vitro drug release, ex vivo skin permeation, in vivo wound healing, cytotoxicity assays, and histopathological studies. Overall, nanoemulsion-based formulations demonstrated enhanced drug solubility, improved skin penetration, sustained drug release, increased therapeutic efficacy, and superior physicochemical stability compared with conventional formulations. These findings highlight the considerable potential of nanoemulgel systems as versatile topical drug delivery platforms for wound healing, skin cancer therapy, photoprotection, and dermatological applications.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7203530769