Clinical and paraclinical predictors of long-term outcomes in patients with acute decompensated heart failure with preserved ejection fraction
Year: 2026
Type: article
Study design: Observational Study
Abstract: Aim . To evaluate the association between intracardiac hemodynamics, clinical parameters, and levels of circulating matrix metalloproteinase-2 and -9 (MMP-2, MMP-9), and tissue inhibitor of metalloproteinases 1 (TIMP-1), with adverse outcomes in patients with acute decompensated heart failure with preserved ejection fraction (HFpEF). Material and methods . One hundred and sixty patients aged 47-96 years hospitalized with acute decompensate HFpEF were included. All patients underwent transthoracic echocardiography and laboratory testing, including determination of the N-terminal pro-brain natriuretic peptide (NT-proBNP) level. Serum samples were analyzed for MMP-2, MMP-9, and TIMP-1 using enzyme-linked immunosorbent assay. Results. Univariate regression analysis revealed significant associations with primary composite endpoint as follows: prior coronary artery disease (CAD), reduced right ventricular systolic function, and elevated NT-proBNP >2514 pg/mL and MMP-2 levels >361 ng/mL. When these parameters were included in the multivariate regression model, MMP-2 levels >361 ng/mL and prior CAD retained statistical significance. Conclusion . An association was demonstrated between MMP-2 levels >361 ng/mL on admission and a history of CAD with an adverse outcome in patients after decompensated chronic HFpEF within a year.
Institution: City Clinical Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7203558882