Work

Antibiotic Resistance of Enterobacteriaceae strains isolated from Urine at the Mother and Child University Hospital in N'Djamena, Chad

Year: 2026

Type: article

Abstract: Infections caused by multidrug-resistant bacteria represent a major challenge to healthcare systems worldwide, particularly in the management of urinary tract infections (UTIs), which are among the most common bacterial infections in both community and hospital settings. This study aimed to investigate the antimicrobial resistance profile of Enterobacteriaceae isolated from urine samples collected at the Mother and Child University Hospital Center (CHU-ME), N'Djamena, Chad. A prospective descriptive study was conducted from June 2024 to February 2026, involving 7,051 urine samples. Bacterial isolation and identification were performed using conventional microbiological methods, the API 20E system, and antimicrobial susceptibility testing according to CA-SFM/EUCAST 2024 guidelines. Among the samples analyzed, 171 (2.4%) yielded positive cultures. Female patients accounted for 60% of cases, and the most affected age group was 21–40 years. High resistance rates were observed to ampicillin (70%), cefotaxime (48.2%), ceftriaxone (43.3%), and ciprofloxacin (44.2%). Resistance to carbapenems was detected in 6.4% of isolates, while multidrug-resistant and ESBL-producing strains were also identified. The findings highlight the emergence of antimicrobial resistance among uropathogens and emphasize the need for continuous surveillance and effective antibiotic stewardship programs.

Source: International Journal of Current Microbiology and Applied Sciences

DOI: 10.20546/ijcmas.2026.1506.001