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Implementation indeterminacy of the 2026 refractory septic shock norepinephrine-equivalent criterion: reproducibility and conformance package

Year: 2026

Type: software

Abstract: Reproducibility archive for a deterministic exact computational validation study evaluating whether published norepinephrine-equivalent dose formula choice, norepinephrine reporting-coordinate normalization, and strict versus inclusive threshold operators can change classification at NEE 0.5. The release includes source-locked specifications, exact rational Python and R implementations, 32 language-neutral conformance vectors, 21 prespecified mutants, boundary outputs, figures, validation reports, and reporting-layer provenance. No patient-level data, clinical outcomes, Monte Carlo sampling, prevalence estimates, or treatment-effect estimates are included. This archive supports the manuscript “Implementation indeterminacy of the 2026 refractory septic shock norepinephrine-equivalent criterion: exact decision boundaries and conformance validation.”

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.21967630

Authors: Toprak, Hasan Burak, Taşkın, Gürhan, Yamanel, Hüseyin Levent

Institution: Gülhane Eğitim ve Araştırma Hastanesi

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W7203580995

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