Optimising osteoarthritis management: An expert consensus on the role of nutraceutical combinations in clinical practice
Year: 2026
Type: article
Abstract: Osteoarthritis (OA) is a leading cause of chronic pain, disability, and reduced quality of life worldwide, with its prevalence increasing due to ageing populations, obesity, and lifestyle-related risk factors. Activity-related joint discomfort (ArJD) similarly affects physically active individuals through repetitive mechanical loading and joint stress, leading to pain, stiffness, reduced range of motion, and impaired mobility. Conventional pharmacological therapies primarily provide symptomatic relief without modifying disease progression and are often associated with long-term adverse effects, creating the need for safe and effective adjunctive interventions. Nutraceuticals, particularly undenatured type II collagen (UC-II®), sodium hyaluronate (Mobilee®), and curcumin, have emerged as promising options due to their beneficial effects on pain, inflammation, cartilage health, and joint function with favourable safety profiles. This expert consensus evaluates the clinical role of UC-II®, Mobilee®, and curcumin in improving outcomes in osteoarthritis and activity-related joint discomfort, with emphasis on pain relief, joint mobility, cartilage regeneration, treatment optimisation, and patient quality of life. Clinical evidence demonstrates that UC-II® significantly improves WOMAC, VAS, joint mobility, cartilage thickness, and functional outcomes, with benefits observed as early as day 7 and sustained up to 6 months, including efficacy in stage III OA and ArJD. Mobilee® improves pain, synovial inflammation, muscular strength, range of motion, and reduces NSAID dependence, particularly in mild-to-moderate OA and individuals with mild joint discomfort. Curcumin provides significant improvements in WOMAC, KOOS, pain scores, range of motion, and exercise-related recovery, supporting its role in both OA and physically active populations. Combination therapy with UC-II® (40 mg), Mobilee® (80 mg), and curcumin (200 mg) has shown significant improvements in WOMAC, VAS, mobility, and functional performance, along with better patient-reported outcomes and quality of life. Appropriate patient selection, clinically validated dosing, and sustained treatment duration further enhance adherence, reduce NSAID dependence, and support long-term joint health. These findings support the integration of evidence-based nutraceutical combinations into contemporary OA and joint health management strategies.
Authors: TV Raja, Indrajit Sardar, John Mukhopadhaya, Balavardhan Reddy, Rajiv Gupta, Sudhir Joshi, Kiran Kharat, Premananda Das, Ronen Roy, Prakash B L, Sachin Ramchandra Tapasvi, Ponnanna KM, Samarth Arya, Chandan Pathak, Abhrajit Ray, Amulya Kumar Singh, Arvind Prasad Gupta, Jaswinder Singh, Sanjay Londhe, Dilip Chand Raja, B Saiphani Chandra, Ramkinkar Jha, Mudit Khanna, Devashis Barick, Buddhadeb Chatterjee, Manoj Kumar Khemani, Sanjoy Sen, Raghu B V, Pavan Chebbi, Prathik Hegde, Umesh Nagare, Ajeya Deshpande, B Jayashankarb, Dinesh Manni, Girish BA, HM Prasanna, Jayavardhan Y B, Kiran Nagaraj, Krishna Kumar, Lingaraju AP, Prashanth KK, Raghavendra Naveen, Rohan Nambiar, Vasudev N Prabhu, Yogish Vijay Kumar, Ajitabh Mishra, Amit Bandyopadhyay, Arnab Karmakar, Arup Kumar Kundu, Chinmay Nath, Kevin Vadadoriya, Nirmalya Guho, Saikat Sarkar, Soumen Kar, Sudesh Saha, Sunit Hazra, Amit Kumar Sinha, Anil Kumar, Baidhnath Kumar, Balmiki Kumar, Janendu Shekhar, Janki Sharan Bahadani, Kumar Gaurav, Kursheed Alam, Rajeev Ranjan, Raju Kumar, Ravi Kumar, Ravi Shankar, Satish Kumar Tiwari, Upendra Prasad, Vinod Kumar Thakur, Anith TV, B Murali Krishna, Babloo Thomas Mani, Hari Prakash, Harish Chandra, J Manimaran, Jaideep Sarda, Lulu Damsas Poolakundan, Manish Samson, Mohamed Shabas Sherief, N Kabilan, P Ramaraju Mudunuri, P V Ramesh, Ranjith Nellore, Taher Muzaffar, Akhilesh Yadav, Amit Mishra, Ankur Singh, Atul Kulshretha, Deepankar Mishra, Dhruv Goel, Faheem Ansari, Gaurav Rajpal, Harish Patni, Harmohan Sahu, Manav Luthra, Manish Trivedi, Manoj Hirani, Md Younus, Sanjay Singh Chauhan, Saurabh Agarwal, Subodh Pathak, Vishal Gupta, Anoop Dhamangaonkar, Apurva Patel, Chintan Rohit Hegde, Himanshu Bendre, Nikhil Shetty, Nilesh Shah, Shreedhar Archik, Subhash Dhiware, Sumedh Joshi, Abhay Shrivastava, Abhilash P Sangtani, Aochin Verma, Ashish Gupta, Harish Rao, Kaustubh Y Kale, Manish Deodhar, Punit Malpani, Romil Rathi, Shailesh Bijwe, Shyam Ravi Shankar Kadambala, Tanmay Chaudhary, Vikas Jain, Vinod Bhuktar, Vivek Tiwari, Abhishek Agarwal, Ananta Saikia, Bitan Maity, Manas Kanti Sarkar, NK Roy, Piyush Agarwal, PK Mallick, Prakash Maheswari, Ravi Shankar Kumar, Roopak Patel, Sanjay Bal, SB Singh, Soham Mondal, Sourav Ghosh, Upal Banerjee, Anjan Ananatharamaia Y, Chethan Nagaraj, Harsha G N, Mahesh Kumar, Raviprasad Kattimany, Shivakumar Y S, Sudhir N Pai, Venkatesh Rathod, Amit Laturkar, Banti Dharma, Dr Chandrashekhar Dixit, Kailas Mohanrao Jorule, Dr Nilesh Kamat, Dr Parimal Kore, Dr Rahul Damle, Dr Randhir Kenjale, Dr Sunny Guggale, Varun Arvind Deshmukh, Vinay Kumar Gautam, Bishal Bhagat, Gourav Chatterjee, Indranil Pal, Kunal Kanti Pal, Pratik Agarwal, Rwik Roy, Smruti Ranjan Panda, Dr Soumya Banerjee, Sudipto Poddar, Sutanu Hazra, Swagatam Jash, Swarnabha Mukherjee, Vikrant Sinharoy, Sweta Pathak, Sanskruti Katkar, Bhakti Gaonkar, Manish R Garg
Institutions: Breach Candy Hospital, S.L. Raheja Hospital, Samarth, Fortis Hospital, Jehangir Hospital, Ruby Hall Clinic, Inlaks & Budhrani Hospital, The Orthopaedic Speciality Clinic, Baba Raghav Das Medical College, Fortis Hospital, Fortis Hospital, Paras HMRI Hospital, Patna, Krishna Institute of Medical Sciences, Wockhardt Hospitals, Apollo Hospitals, NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital, Apollo Hospitals, Manipal Hospital, Sahyadri Hospital, Medicover Hospitals, Sparsh Hospital, Apollo Hospitals, Apollo Hospitals, Narayana Health, R. G. Kar Medical College and Hospital, Medical College and Hospital, Kolkata, KVG Medical College & Hospital, Sree Gokulam Medical College and Research Foundation, Kempegowda Institute of Medical Sciences, Max Super Speciality Hospital, Saifee Hospital, Kokilaben Dhirubhai Ambani Hospital
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7203583545