Application of the mesenchymal stem cell secretome for the treatment of horses with chronic obstructive pulmonary disease (clinical case)
Year: 2026
Type: article
Abstract: Mesenchymal stem (stromal) cells (MSC) are multipotent stromal cells that are able to modulate the immune response to tissue damage and promote tissue repair in vivo. The prospects of using drugs based on the secretion products of mesenchymal stromal cells are encouraging for both human medicine and animal treatment. However, the current scientific and practical data cannot be fundamental for use in clinical settings due to insufficient research. This work analyzes the experience of using the secretome of mesenchymal stromal cells (MSC) in cardiorespiratory diseases of horses. A secretome is a collection of all biologically active substances secreted by mesenchymal stem cells (MSC) into the extracellular space. The introduction of drugs based on the MSC secretome into veterinary medicine is of great scientific and practical interest. A horse was used as a model for studying the effectiveness of MSC. The article presents clinical observations and focuses on a promising scientific and practical field of equestrian medicine - the study of the effect of mesenchymal stem cell secretion products on the physiological and reparative regeneration of the cardiorespiratory system in chronic obstructive bronchial and lung diseases. To date, the complex etiotropic and pathogenetic therapy of chronic obstructive pulmonary disease (COPD) includes steroid anti-inflammatory drugs, broad-spectrum antibiotics, antiprotozoal and fungicidal agents, bronchodilators and substances with a desensitizing effect. This therapy leads to a rapid onset of shortterm remission. However, from the standpoint of violation of the barrier properties of the respiratory system, the ongoing therapeutic measures are not aimed at restoring natural protection and accelerating the regeneration of damaged tissues. Thus, the need for veterinary drugs that qualitatively restore lost cells is urgent.Mesenchymal stem (stromal) cells (MSC) are multipotent stromal cells that are able to modulate the immune response to tissue damage and promote tissue repair in vivo. The prospects of using drugs based on the secretion products of mesenchymal stromal cells are encouraging for both human medicine and animal treatment. However, the current scientific and practical data cannot be fundamental for use in clinical settings due to insufficient research.
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7203645274