Síndrome de Parry-Romberg con neuralgia de trigémino contralateral: ¿una combinación rara o un hallazgo incidental?
Year: 2026
Type: article
Study design: Case Report
Abstract: Background: Parry-Romberg syndrome, also known as progressive hemifacial atrophy, is a rare acquired neurocutaneous disorder of unclear etiology. Proposed pathogenic mechanisms include trauma, autoimmune processes, sympathetic nervous system dysfunction, and infections. The disease predominantly affects children and young adults, with a female predominance. Clinical manifestations may involve neurological, ophthalmological, and musculoskeletal systems. The course is typically insidious, progressive, and self-limited, stabilizing over a period of 2 to 20 years. Diagnosis is primarily clinical and may be supported by imaging and histopathological findings. Treatment aims to control disease activity and minimize long-term sequelae. Objectives: to report a case of unilateral progressive hemifacial atrophy incidentally associated with contralateral trigeminal neuralgia. Case description: a 69-year-old woman with a history of remote facial trauma developed self-limited, asymptomatic left progressive hemifacial atrophy. She also presented with a 15-year history of right trigeminal neuralgia refractory to medical therapy and radiosurgery. Magnetic resonance imaging demonstrated a right-sided neurovascular conflict involving the anterior inferior cerebellar artery. Surgery: microsurgical decompression of the right trigeminal nerve was performed through a retrosigmoid approach, with interposition of polytetrafluoroethylene between the nerve and the offending vessel. No perioperative complications occurred. Conclusion: we report a case of late-diagnosed left Parry-Romberg syndrome associated with right trigeminal neuralgia secondary to a neurovascular conflict successfully treated with microsurgical decompression. The opposite laterality of both conditions and intraoperative confirmation of the vascular conflict suggest an incidental coexistence rather than a direct pathophysiological relationship.
Institutions: Hospital de Especialidades Eugenio Espejo, Hospital Vozandes
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7203674428