Year: 2026
Type: book
Abstract: Seeking to deliver therapeutic agents to the central nervous system (CNS) remains one of the great challenges of drug design due to the protective physiological barriers which limit the transport of drugs to the brain. Of the many alternative methods, nose-to-brain drug delivery has become a popular non-invasive drug delivery method that could help to transport the therapeutic agent directly to the CNS and limit the problems associated with conventional systemic drug application methods. This edited book offers a short and succinct summary about the principles, difficulties, approaches towards the formulation of drugs and recent advances in nose-to-brain drug delivery. It provides a full overview of the key elements of nasal anatomy, physiology, mucociliary clearance, pathways for drug transport, and barriers to successful brain targeting. The focus is placed on the advanced pharmaceutical delivery systems such as microemulsions, nanoemulsions, micelles, dendrimers, nanogels, solid lipid nanoparticles, nanostructured lipid carriers, polymeric nanoparticles and in situ gelling systems. Their formulation principles, characterization, advantages, limitations and potential applications in CNS disorders are discussed throughout the book. Additionally, it emphasizes the significance of the use of nanotechnology and mucoadhesive strategies to enhance drug solubility, stability, nasal residence time, permeability and brain targeting. Neurological and neuropsychiatric disorders and emerging strategies for targeted delivery to brain Tumors are also discussed. The book will prove to be a valuable resource for any student or postgraduate studying pharmacy, for academicians and pharmaceutical scientists involved in drug delivery and nanotechnology, as well as for professionals. The convergence of current research with basic concepts, to give a clear picture of the fast evolving arena of nose to brain delivery. Genetic modification, platform optimization, safety and toxicity of the mucosa, and the reproducibility and quality of the device, regulatory requirements, and translation to the clinical setting still present problems. Further research and multi-disciplinary studies will be needed to translate the promise of potential nose-to-brain drug delivery systems into the clinical reality of drug delivery. We hope this book will not only help provide scientific insights to readers but also inspire more studies and developments in areas aimed at targeted CNS drug delivery and pharmaceutical nanotechnology.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7203684844