Get started
Work

A cross-modal generative model for incomplete and degraded prostate MRI with multicentre clinical validation

Year: 2026
Type: preprint
Abstract: Missing or degraded sequences can limit prostate multiparametric MRI. We developed MSCNet, a sequence-conditioned cross-modal generative framework for reconstructing unavailable contrasts and restoring degraded acquisitions. Across ten completion tasks, task-specific MSCNet achieved mean structural similarity of 0.818 versus 0.798 for the strongest task-matched comparators; matched-capacity analyses showed larger differences in lesion fidelity and boundary preservation. In a blinded 1,000-case reader study, overall image quality met the prespecified non-inferiority criterion for DWI, ADC and T2W completion, but not T1W. In a separate 200-case diagnostic assessment, AUCs for clinically significant cancer were 0.860 with acquired images, 0.841 with MSCNet and 0.797 with baseline-generated images. A locked 186-case three-hospital cohort supported multicentre transportability. These retrospective results support quality-controlled cross-modal reconstruction as an adjunct to acquired prostate MRI.
DOI: 10.64898/2026.08.16.745066
Authors: Siyuan Ma, Liang He, Mengying Zhu, Yi Chai, Mengyao Lyu, Haowei Wang, Qizhen Lan, HaoBo Sun, Qixin Zhang, Jingli Chen, Xiaobing Wei, Jiaming Liu, Guiqin Liu, Qianwen Zhang, Yang Liu, Dacheng Tao, Guangyu Wu
Institutions: Nanyang Technological University, Stanford University, Shanghai Jiao Tong University, Renji Hospital, National University of Singapore, Tongji University, Shanghai East Hospital, The University of Texas Health Science Center at Houston, Southeast University, Changhai Hospital
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W7203714656
Cites: 34
Cited by:
Related to: 10