Supplementary materials: Real-world treatment patterns and clinical outcomes of patients with primary biliary cholangitis in the United States
Year: 2026
Type: supplementary-materials
Abstract: These are peer-reviewed supplementary materials for the article 'Real-world treatment patterns and clinical outcomes of patients with primary biliary cholangitis in the United States' published in the Journal of Comparative Effectiveness Research.Supplementary Table 1: Diagnosis and procedure codes used in the eligibility criteria, baseline characteristics, and clinical outcomes analyses.Supplementary Figure 1: Time to each individual clinical outcome in the untreated cohort.Supplementary Figure 2: Time to each individual clinical outcome in the 1L cohort.Supplementary Figure 3: Time to each individual clinical outcome in the 2L+ cohort.Background & aim: Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease that can lead to increased morbidity and mortality. This study described real-world treatment patterns and clinical outcomes by line of treatment among patients with PBC in the US. Materials &methods: Adults (≥18 years) diagnosed with PBC on or after 1 January 17 were identified in the IQVIA PharMetrics R ? Plus database and grouped into newly diagnosed, first-line (1L) and second-line or more (2L+) cohorts. Index date was initial PBC diagnosis or initiation of 1L or 2L therapy; follow-up continued until the earliest of end of continuous enrollment, death or data end. Time to treatment initiation, treatment discontinuation and negative clinical outcomes were assessed with Kaplan–Meier analysis. Results: The newly diagnosed, 1L and 2L+ cohorts included 1748, 1659 and 181 patients, respectively (average age at index: 52.7–54.5 years; female: 84.2–89.0%). Of the newly diagnosed cohort, 34.8% did not initiate PBC treatment within 1.5 years post-diagnosis. In the 1L cohort, median time from diagnosis to 1L initiation was 1.2 months; median time from 1L initiation to 1L discontinuation/2L initiation was nearly 5 years. In the 2L+ cohort, median time from 2L initiation to 2L discontinuation was approximately 4 years. In the untreated, 1L, and 2L+ cohorts, 18.9%, 14.4% and 19.3% of patients developed ≥1 negative clinical outcome post-index (usually cirrhosis). Conclusion: Results of this US population-based study demonstrate a potential unmet need for early intervention and effective treatment options for patients with PBC, as one in three patients with PBC remain untreated years after diagnosis.
Source: Figshare
Language: English
Topic: Liver Diseases and Immunity
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7203753302