Factors associated with disseminated intravascular coagulation in postpartum hemorrhage at university hospital Androva, Mahajanga, Madagascar
Year: 2026
Type: article
Study design: Observational Study
Abstract: Introduction: Disseminated Intravascular Coagulation (DIC) is a severe complication of Postpartum Hemorrhage (PPH) and a major cause of maternal mortality.This study aimed to identify factors associated with DIC in women with PPH. Materials and methods: A retrospective analytical case-control study was conducted from January 2020 to December 2024 Androva University Hospital, Mahajanga (Madagascar).Cases were parturients with DIC complicating PPH, while controls had PPH without DIC (1:3 ratio).Sociodemographic, obstetrical, clinical, biological, management, and maternalfetal outcome data were analyzed using SPSS version 26 .Statistical significance was set at p < 0.05.Results: Eighty-eight parturients were included (22 cases, 66 controls).Systolic blood pressure <90 mmHg (OR = 19.11;p = 0.003), was significantly associated with DIC.Uterine atony was significantly associated with DIC (OR = 5.57; p = 0.001).Hemoglobin <70 g/L, thrombocytopenia <150 G/L, and prothrombin time <70% were also associated with DIC.Maternal mortality was significantly higher in cases (81.82% vs 9.09%; p < 0.001).Conclusion: DIC complicating PPH is associated with severe clinical and biological abnormalities and high maternal mortality, highlighting the need for early diagnosis and prompt multidisciplinary management.
Institutions: Université de Mahajanga, University of Toamasina
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7203777602