Analisis Profil Bakteri dan Pola Resistensi Bakteri Penyebab Pneumonia terhadap Antibiotik pada Kultur Sputum
Year: 2026
Type: article
Abstract: Pneumonia remains a leading cause of infection-related mortality worldwide, with increasing antibiotic resistance posing a significant challenge to effective treatment. This study aims to determine the antibiotic resistance patterns of pneumonia-causing bacteria in sputum cultures at BBLKM Palembang in 2024. This quantitative descriptive research utilized secondary data from 183 samples obtained through total sampling. The majority of respondents were male (53%) and elderly aged ≥ 60 years (59%). Results showed a dominance of Gram-negative bacteria, primarily Klebsiella pneumoniae (47.54%) and Pseudomonas aeruginosa (27.87%). Amikacin demonstrated the highest sensitivity (66.12%), while significant resistance was observed against third generation cephalosporins, specifically Cefotaxime (42.08%) and Ceftriaxone (35.52%). The prevalence of MultiDrug Resistant (MDR) organisms reached 36.6%, with the highest rates found in Acinetobacter baumannii (72.7%). In conclusion, the high resistance to standard cephalosporins and the emergence of MDR strains underscore the urgent need for strengthened Antimicrobial Stewardship (AMS) and infection control protocols in regional reference laboratories to guide effective empirical therapy.
Institution: Universitas Jambi
Language: English
Subfield: Microbiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7203778490