Work

Dermal PBPK modelling of clobetasol propionate cream: Guiding IVPT design and assessing the impact of globule size on skin permeation

Year: 2026

Type: dataset

Abstract: This dataset contains the Simcyp Simulator V23R2 workspaces and associated data files used to simulate the in vitro and in vivo permeation of clobetasol propionate (CbP) described in the paper "Dermal PBPK modelling of clobetasol propionate cream: Guiding IVPT design and assessing the impact of globule size on skin permeation", together with the raw experimental data generated and reported in this work. The experimental data cover in vitro permeation (IVPT), in vitro release (IVRT), skin thickness, skin extraction and surface-wash recovery and formulation characterisation.

Source: Mendeley Data

DOI: 10.17632/jj5ny3s6mt

Authors: Zhang, Yanling, Murthy, S. Narasimha, Rangappa, Srinath, Polak, Sebastian, Paterson, Daniel, Dancik, Yuri, Tabosa, Alice Maciel, Coleman, Lucy, Thakur, Kanika, Tsakalozou, Eleftheria, Ghosh, Priyanka, Clarke, James F.

Institutions: Simcyp (United Kingdom), United States Food and Drug Administration

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: U.S. Food and Drug Administration

OpenAlex ID: W7203782080

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Related to: 10