Year: 2026
Type: article
Abstract: PIEZO1 and PIEZO2 are mechanically activated ion channels central to touch, proprioception, and vascular development. Although purified PIEZO1 gates in lipid bilayers, cellular mechanotransduction relies on interacting proteins that tune channel sensitivity, kinetics, and spatial activation via three mechanisms: reshaping the membrane microenvironment, conveying forces via extracellular/intracellular tethers, or directly modifying gating energetics. We review PIEZO-associated proteins and propose a unified framework linking these mechanotransduction complexes to precision medicine.
Language: English
Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,490
OpenAlex ID: W7203787045