Gut Microbiome Modulation for Colorectal Cancer Therapy: Biomolecule‐Integrated Nanotherapeutic Strategies
Year: 2026
Type: article
Abstract: ABSTRACT Cancer is characterized by uncontrolled growth of cells destroying surrounding cells and tissues that can spread through metastasis. Colorectal cancer (CRC) can be developed from a non‐carcinogenic polyp that turns into malignant if untreated. Apart from genetic traits, change in lifestyle, unhealthy food habits play a major role in developing CRC. The usual therapeutic options exhibit a number of severe side effects. Alongside restricting the cancer cell growth, it also damages the healthy cells as targeting of cancer therapeutics has always been challenging. In effective delivery of anticancer drugs, nanocarriers play a pivotal role due to their targeting ability, effective tissue permeability, and controlled drug release pattern. Modulating gut microbiota and repurposing their effect is gaining interest as an advanced and sustainable therapeutic option in clinical practices. This has opened the door in prevention and therapy of CRC using engineered gut microbiota. This review provides a consolidated framework of gut microbiome dysbiosis in CRC and discusses the effect of biomolecule‐integrated nanotherapeutic strategies, microbiome modulation approaches, and nanoparticle‐mediated delivery systems for improved CRC management.
Source: ChemistrySelect
Institutions: Brainware University, Adamas University
Language: English
Topic: Bacterial Cancer Therapy
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,880
OpenAlex ID: W7203873175