Work

Clinical applications of matrix metalloproteinases and their tissue inhibitors in periodontology: a scoping review of the human evidence

Year: 2026

Type: preprint

Abstract: The matrix metalloproteinase (MMP)–tissue inhibitor of metalloproteinase (TIMP) axis has been investigated for chairside biomarker testing and host-response modulation in clinical periodontology. However, the accumulated evidence regarding its diagnostic utility has not yet been synthesized. This scoping review mapped human studies that measured MMP-8, MMP-9, MMP-13, TIMP-1 or TIMP-2 across the periodontal continuum.

DOI: 10.17605/osf.io/984jz

Authors: Akira Hasuike, Birke Koca-Ünsal, Jelena Roganović, Esra Güzeldemir-Akçakanat, Maria Eugenia Guerrero Acevedo, Khadija Sikkou, Taleessa Vieira Gomes, Adetola Emmanuel Babalola, Dr. Carel Brigi, Akhilanand Chaurasia

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7203909045

Cites:

Cited by:

Related to: 10