Glycine Attenuates Noise Stress–induced Alterations in Antioxidant Enzymes and Brain Neurotransmitters
Year: 2026
Type: article
Abstract: Glycine, the simplest amino acid, acts as an inhibitory and excitatory neurotransmitter that regulates central nervous system functions. Other biochemical molecules that have an impact on bodily functions are metabolized with the help of glycine. Stress is a common challenge encountered during everyday activities. There has been a correlation between neurological functions and the perturbation of cerebral levels of neurotransmitters. The study was designed to find out that glycine supplementation on an antioxidant system under noise stress. Eighteen rats were randomly allocated into three groups: control, noise stress, and noise stress + glycine. Noise stress was given to the animals by exposing to the sound >110 dB for 3 hrs. After 15 days, rats were euthanized, and brain tissues were collected for antioxidant analysis including Malondialdehyde, Superoxide dismutase (SOD) and catalase while neurochemical estimations including Dopamine (DA) and Serotonin. Results showed that glycine attenuates stress effects and significantly (p<0.05) improves the antioxidant system with its neurochemical contents of rats. Antioxidant enzymes, dopamine and serotonin levels increased >95% following glycine administration. It is concluded that glycine in noise stressed rats significantly improved antioxidant defense system and improved neurochemical functions in rats.
Authors: Irfan Sajid, Hafsah Khan, Munawar Abbas
Institution: Federal Urdu University
Language: English
Topic: Noise Effects and Management
Subfield: Acoustics and Ultrasonics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W7204036622