Coexistent IgG4-Related Sclerosing Cholecystitis and Xanthogranulomatous Cholecystitis in the Gallbladder: A Case Report
Year: 2026
Type: article
Study design: Case Report
Abstract: A man in his 70s had a history of immunoglobulin G4 (IgG4)-related lung disease. Abdominal ultrasonography revealed smooth wall thickening with a preserved layered structure in the gallbladder neck. The fundus showed irregular wall thickening and layered structure loss. These findings suggest the existence of two pathological entities within the gallbladder. Malignancy could not be ruled out. A cholecystocolonic fistula developed, and radical cholecystectomy and partial transverse colon resection were performed. A histopathological examination revealed IgG4-related sclerosing cholecystitis (IgG4-CC) of the neck and body and xanthogranulomatous cholecystitis (XGC) of the fundus. The fistula originated from the XGC lesion.
Source: Internal Medicine
Authors: Takaki Okuyama, Kazuyuki Matsumoto, Takayoshi Miyake, Susumu Shinoura, Tsuyoshi Okada, Hiromasa Takeda, Kosaku Morimoto, Shogo Kimura, Kensuke Takei, Ryuta Takenaka
Institutions: Tsuyama Chuo Hospital, Okayama University Hospital
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7204104338