Joint Glycemic–Insulin Resistance Phenotype Across Acute and Post-Acute COVID-19: A Systematic Review and Meta-analysis of Etiologic and Prognostic Evidence
Year: 2026
Type: preprint
Abstract: This systematic review and meta-analysis evaluates whether SARS-CoV-2 infection is associated with the emergence or persistence of a joint glycemic–insulin resistance phenotype across acute and post-acute COVID-19 and whether the acute clinical expression of this phenotype is associated with short-term all-cause mortality and invasive mechanical ventilation. Eligible studies must assess both a glycemic component and an insulin-resistance or insulin-sensitivity component in the same participants. Etiological, longitudinal, mechanistic, and non-combinable prognostic evidence will be synthesized using structured synthesis without meta-analysis (SWiM), while clinically and methodologically comparable prognostic outcomes will be synthesized using random-effects meta-analysis. This registration was created after completion of study selection, standardized data extraction, and formal risk-of-bias assessment, and after exploratory feasibility analyses, but before the definitive quantitative synthesis and certainty-of-evidence assessment using GRADE.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7204145224