Year: 2026
Type: article
Abstract: Cancer remains a leading cause of morbidity and mortality globally, highlighting the significant need for more effective and less aggressive treatments. Quinoxaline derivatives, which are compounds with flexible chemical structures, have shown promise as potential anticancer drugs. In this study, a series of novel quinoxalines derivatives were developed for their potential anticancer properties. The compounds were synthesized from their corresponding 2-chloro-3-methoxyquinoxaline, and their structures were confirmed through IR, NMR, and mass spectroscopic analyses. The anticancer efficacy of these quinoxalines derivatives were assessed in vitro against MCF-7 breast cancer cells at a concentration of 10 μg, revealing moderate to significant cytotoxic effects. Compounds 3j, 3d, and 3h, which feature a metthoxy groups on phenyl ring, exhibited particularly notable activity.
Institution: Telangana University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W7204145538