Atosiban versus nifedipine for the management of preterm labor: a systematic review and meta-analysis of randomized controlled trials
Year: 2026
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Objective: To compare the efficacy, maternal safety, and neonatal outcomes of atosiban versus nifedipine in the management of preterm labor, with particular attention to neonatal intensive care unit (NICU) admission rates. Data sources: PubMed, EBSCOHost, ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform (ICTRP), and the Cochrane Central Register of Controlled Trials were systematically searched up to May 25, 2025. No language restrictions were applied. Study selection: Randomized controlled trials (RCTs) comparing atosiban and nifedipine in women with clinically diagnosed preterm labor were included, provided they reported at least one outcome related to pregnancy prolongation. Six RCTs comprising 1,070 patients met inclusion criteria. Data collection: Two reviewers independently extracted data on efficacy, maternal adverse effects, and neonatal outcomes using a standardized form. Risk of bias was assessed with the Cochrane Risk of Bias 2 (RoB 2) tool. Data synthesis: =69.8%) and warranting cautious interpretation. No significant differences were observed for neonatal death, sepsis, or hemorrhagic disease. Conclusion: PROSPERO CRD420251065426.
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7204154886