Work

Metabolomic and peptidomic insights into camel colostrum–derived protein hydrolysates with potential anti-hypercholesterolemic activities

Year: 2026

Type: article

Abstract: : A631.81 ± 1.71, F6: 46.94 ± 2.89, N6; 46.63 ± 4.5) of CCH were higher in all cases except F6: 74.52 ± 12.7 and N6: 56.7 ± 15.39 compared with MCMHs with F6: 70.77 ± 8.65 and N6: 53.32 ± 2.6. Molecular docking revealed that identified peptides disrupt PL and CE enzyme-substrate interactions by binding at hotspot sites and distant residues. Peptides, LHPVPQPLVPVI and PQPVPQTPMIPPQSL, were predicted to act as both PL and CE inhibitors, warranting future research via peptide synthesis or in vivo studies. Metabolomics also confirmed diverse post-hydrolysis metabolites, positioning CCHs as promising nutraceuticals for obesity and well-being.

Source: Journal of Dairy Science

DOI: 10.3168/jds.2026-28580