Work

Radical–carbanion relay enabled by earth-abundant titanium: carboxylation of 1°, 2°, and 3° benzyl chlorides with CO 2

Year: 2026

Type: article

Abstract: A Ti( iii )-catalyzed reductive carboxylation of 1°, 2°, and 3° benzyl chlorides with CO 2 proceeds via a radical-carbanion relay, enabling the additive-free synthesis of arylacetic acid drugs under O 2 -tolerant conditions without precious metals.

Source: Chemical Science

DOI: 10.1039/d6sc04813g

Authors: Lei Fan, Jiwu Zhao, Huaming Sun, Weiqiang Zhang, Guofang Zhang, Yajun Jian, Ziwei Gao

Institutions: Shaanxi Normal University, Xinjiang Normal University, Yan'an University

Language: English

Topic: Carbon dioxide utilization in catalysis

Subfield: Process Chemistry and Technology

Field: Chemical Engineering

Domain: Physical Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, Higher Education Discipline Innovation Project, Key Research and Development Projects of Shaanxi Province, Natural Science Basic Research Program of Shaanxi Province

Awards: 茂钛/钯协同接力催化氮杂环化反应研究, G23277181, G3513459421, G4110143010, G4786746168, G5222817047, G6860969088

OpenAlex ID: W7204196639

FWCI:

Cites: 74

Cited by:

Related to: 10